The other name of acetaminophen is paracetamol and this is a widely used drug all over the world as a pain killer and for controlling the fever. Acetaminophen was approved by the FDA in 1951 and Tylenol the most popular brand came into the market. The action of acetaminophen is still not clear. Acetaminophen is available in different dosages in the U.S.325 and 500 mg immediate –release and a 650mg extended release which is found to be very effective in the treatment of arthritis. Various forms of suspensions, chewable tablets and dissolvable tablets are also available in the market. The drug is sold over the counter world wide.

American Association of the poison control states that the commonly used analgesic and antipyretic agent acetaminophen has toxicity, if used for a longer duration. This can lead to hepatic failure which will lead to a state of liver transplantation. Acetaminophen toxicity in the U.S has replaced viral hepatitis as the normal cause for hepatic failure. A series of pharmaceutical regulatory of modifications are initiated to bring down the menace of acetaminophen .As a step to find solution to bring down the threat of the drug FDA s contemplating on the withdrawal of acetaminophen from the analgesic combination drugs and is also considering the reduction in the recommended daily dosage. Certain other changes the FDA is considering are as follows,

Dosage in pediatric cases, limiting the package size, acetaminophen sedative combinations, safe daily dose in acute liver problems, safe daily dose for patients in good physical conditions.

In the year of 2001 FDA asked the manufactures of combination drugs to limit the dosage of acetaminophen to 325 mg per tablet and capsule. The FDA strongly is in the assumption that such a move will bring down the risk of liver problems, decrease the possibilities of hepatoxicity and also deaths related to the overdose of the drug.

Side Effects

Many people are of the belief that Tylenol is a safest drug and is prescribed as a substitute to ibuprofen with less side effects, but  on the contrary, serious side effects have been noticed by the continuous usage of  acetaminophen. A study during the year of 2010 revealed  that  acetaminophen leads to male infertility problems and usage during pregnancy is also very harmful. There is always a possibility for liver injury and the other noted side effects are , risk of leukemia in adults, asthma and eczema among children. Excess dosage of acetaminophen has become a real problem on the stressful healthcare system of the U.S. Approximately five hundred deaths are reported every year as a result of overdose and acetaminophen is a major cause for fifty percent of  liver failure cases in the U.S

Side effects revealed

Studies revealed that Tylenol is more harmful than hydrocodone, the toxicity of acetaminophen was traced only six years ago. The study also reveals that out of six hundred patients died without a liver transplant because of overdose of the drug.

Consuming Tylenol along with alcohol can end up in liver injury cases.Fda asked the manufactures of the drug to come out with proper warning of the drug and also limited the usage of acetaminophen in combination drugs. Tylenol liver damage lawyers have been demanding this step for quite some time.

Lawyers are fighting liver damage cases caused by Tylenol all over the country. If you are a victim of Tylenol or anyone of your beloveds suffered liver injury, call an attorney and you are sure to get a compensation.

Cialis is a market name for a drug known as Tadalafil. It is a PDE5 inhibitor, which is mostly used in the treatment of erectile dysfunction and pulmonary arterial hypertension. The tablets are yellow, almond quoted and round shaped. They are available in doses of ten mg and twenty mg. The drug has been approved for sale in the US.

The drug has been nicknamed the Weekend Pill, because it has a thirty six hour period of effectiveness.

As a result, it is only recommended if it is needed. In addition, the drug is only supposed to be taken once daily. As has been noted, this drug is meant for patients that have erectile dysfunction and has been said to have a longer half-life as compared to other drugs like Viagra.

As a result, the drug ensures that there is a longer duration of action, and this is one of the reasons as to why it is often referred to as the weekend pill.

In order to understand what the drugs do, it is vital that we understand how erection works. A sexually stimulated penile erection is caused by increased blood flow as a result of relaxation of the penile arteries and corpus cavernosum smooth muscle.

The erection is mediated by the release of nitric oxide from the endothelial cells and nerve terminals, thus, stimulating the synthesis of cGMP. The drug inhibits phosphodiesterase type 5, which enhances erectile function by increasing cGMP amounts.

As is the case with most drugs, Cialis has certain side effects. Some of the commonest side effects of the drug include indigestion, headache, back pain, flushing, muscle aches, runny nose and stuffy nose among others. However, many of these side effects disappear after a few hours.

If the side effects do not go away, you should probably contact a doctor, especially if the effects are in relation to widening of blood vessels. In 2005, it was found that Cialis is also associated with vision impairment. However, most of the patients that presented such symptoms had underlying vascular and anatomic risks factors, for example, above the age of fifty, coronary artery disease, hypertension, diabetes, hypertension and hyperlipidemia among others.

It is, therefore, vital that you understand some of these risk factors before you go ahead and take the drugs. You should also point these factors out to your doctor, so that the necessary precautions are taken. PDE5 inhibitors like Cialis have been known to cause low blood pressure or hypotension.

It is, therefore, vital that organic nitrates not be taken for at least forty eight hours after taking the last Cialis dose. This is because; using these nitrates might increase the risk of hypotension among other side effects.

In addition, since people that have taken these drugs cannot take organic nitrates, they should seek medical advice if they experience chest pains within 48 hours of having taken the drugs.

Overall, it should be noted that the drugs are used for the treatment of erectile dysfunction. They have been established to last for a long time, and you will not have to take another dose of the drugs.